BA-AZT1 is an inhibitor of HBV polymerase and sodium taurocholate cotransporting polypeptide (NTCP). BA-AZT1 inhibits the secretion of viral capsid proteins HBsAg and HBeAg with IC50 of 0.65 µM and 13.42 µM, respectively, and inhibits HBV DNA replication with IC50 of 0.70 µM.

Physicochemical Properties

Molecular Formula	C43H63N5O7
Molecular Weight	761.99
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of pentacyclic triterpene conjugates as HBV polymerase/NTCP dual-targeting inhibitors with potent anti-HBV activities. Bioorg Chem. 2025 Jan;154:108054.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3124 mL	6.5618 mL	13.1235 mL
	5 mM	0.2625 mL	1.3124 mL	2.6247 mL
	10 mM	0.1312 mL	0.6562 mL	1.3124 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.