Aurora A inhibitor 4 (compound C9) is a potent inhibitor of Aurora A with GI50 of 4.26 and 7.08 μM in DU 145 cells and HT-29 cells, respectively.

Physicochemical Properties

Molecular Formula	C22H23N5O3
Molecular Weight	405.45
CAS #	371224-09-8
SMILES	CCOC1=CC2=C(N=C(N=C2C=C1)NC3=NC(CC(=O)N3)C4=CC=C(C=C4)OC)C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Aurora A
References	[1]. Computational approach to the identification of novel Aurora-A inhibitors. Bioorg Med Chem. 2011 Jan 15;19(2):907-16.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.4664 mL	12.3320 mL	24.6640 mL
	5 mM	0.4933 mL	2.4664 mL	4.9328 mL
	10 mM	0.2466 mL	1.2332 mL	2.4664 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.