HIV-1 inhibitor-79 (Compound 3k) is an HIV inhibitor that exhibits significant inhibitory activity against HIV-1 and its common mutants (IC50 for HIV-1, K103, L100I, and E138K are 1.9, 1.9, 8.7, and 11 nM, respectively), and has low cytotoxicity and a high selectivity index (CC50 = 21.95 μM, SI = 11478). In addition, HIV-1 inhibitor-79 also exhibits antiviral activity against HIV-2, with an EC50 value of 6.14 μM, and can significantly inhibit the activity of HIV-1 reverse transcriptase (IC50 = 25 nM).

Physicochemical Properties

Molecular Formula	C21H17N7O
Molecular Weight	383.41
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile. Eur J Med Chem. 2025 Jan 5;281:117033.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6082 mL	13.0409 mL	26.0817 mL
	5 mM	0.5216 mL	2.6082 mL	5.2163 mL
	10 mM	0.2608 mL	1.3041 mL	2.6082 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.