Ap4dT is an inhibitor of human adenylate kinase isoenzyme 1 (hAK1), inhibiting ATP and ADP synthesis with IC50 of 42 μM and 38 μM, respectively.

Physicochemical Properties

Molecular Formula	C20H41N11O20P4
Molecular Weight	879.50
CAS #	1146545-74-5
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Synthesis, kinetic studies, and QSAR of dinucleoside polyphosphate derivatives as human AK1 inhibitors. Bioorg Chem. 2024 Jul;148:107432.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.1370 mL	5.6850 mL	11.3701 mL
	5 mM	0.2274 mL	1.1370 mL	2.2740 mL
	10 mM	0.1137 mL	0.5685 mL	1.1370 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.