Amezinium metilsulfate stimulates alpha and beta-1 receptors and inhibits norepinephrine and tyramine absorption.

Physicochemical Properties

Molecular Formula	C12H15N3O5S
Molecular Weight	313.33
Exact Mass	313.073
Elemental Analysis	C, 46.00; H, 4.83; N, 13.41; O, 25.53; S, 10.23
CAS #	30578-37-1
Related CAS #	30578-37-1(Amezinium metilsulfate); 41658-78-0 (Amezinium)
PubChem CID	71926
Appearance	White to off-white solid powder
LogP	1.704
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Heavy Atom Count	21
Complexity	285
Defined Atom Stereocenter Count	0
SMILES	COC1=CC(N)=CN=[N+]1C2=CC=CC=C2.O=S(OC)([O-])=O
InChi Key	ZEASXVYVFFXULL-UHFFFAOYSA-N
InChi Code	InChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4)
Chemical Name	6-methoxy-1-phenylpyridazin-1-ium-4-amine;methyl sulfate
Synonyms	LU-1631; LU 1631; LU1631; Regulton; Risumic
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia. Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9.

Additional Infomation

Amezinium metilsulfate is an azaheterocycle sulfate salt of amezinium. It is a sympathomimetic drug which suppresses noradrenaline reuptake and thereby elevating blood pressure. It is used for the treatment of low blood pressure in patients undergoing dialysis. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor, an antihypotensive agent, a sympathomimetic agent and an adrenergic uptake inhibitor. It contains an amezinium.

Solubility Data

Solubility (In Vitro)	DMSO: ~63 mg/mL (~201.1 mM) Water: ~32 mg/mL Ethanol: ~5 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 11.11 mg/mL (35.46 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1915 mL	15.9576 mL	31.9152 mL
	5 mM	0.6383 mL	3.1915 mL	6.3830 mL
	10 mM	0.3192 mL	1.5958 mL	3.1915 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.