Alnustone is a non-phenolic diphenylheptane compound found in herbs and spices and is a component of Alpiniae Katsumada i. Alnustone has anti-emetic and anti~inflammatory properties.

Physicochemical Properties

Molecular Formula	C19H18O
Molecular Weight	262.35
Exact Mass	262.135
CAS #	33457-62-4
PubChem CID	5317598
Appearance	White to yellow solid powder
Density	1.1±0.1 g/cm3
Boiling Point	442.9±34.0 °C at 760 mmHg
Melting Point	60.5-61℃
Flash Point	170.9±24.9 °C
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.604
LogP	4.16
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	6
Heavy Atom Count	20
Complexity	328
Defined Atom Stereocenter Count	0
SMILES	C1=CC=C(C=C1)CCC(=O)/C=C/C=C/C2=CC=CC=C2
InChi Key	OWMJDOUOHDOUFG-FNCQTZNRSA-N
InChi Code	InChI=1S/C19H18O/c20-19(16-15-18-11-5-2-6-12-18)14-8-7-13-17-9-3-1-4-10-17/h1-14H,15-16H2/b13-7+,14-8+
Chemical Name	(4E,6E)-1,7-diphenylhepta-4,6-dien-3-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. An efficient synthesis of alnustone, a naturally occurring compound. Turkish Journal of Chemistry 27(1):31-34. [2]. Three non-phenolic diarylheptanoids with anti-inflammatory activity from Curcuma xanthorrhiza. Planta Med. 1993 Oct;59(5):451-4.
Additional Infomation	Alnustone is a diarylheptanoid. Alnustone has been reported in Curcuma xanthorrhiza, Alpinia hainanensis, and other organisms with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~381.17 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.5 mg/mL (9.53 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.53 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.8117 mL	19.0585 mL	38.1170 mL
	5 mM	0.7623 mL	3.8117 mL	7.6234 mL
	10 mM	0.3812 mL	1.9059 mL	3.8117 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.