ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), which binds to inosine monophosphate cyclohydrolase (IMPCH) with Ki of 0.13 μM.

Physicochemical Properties

Molecular Formula	C4H4N4O3S
Molecular Weight	188.17
CAS #	67095-44-7
Appearance	Solid powder
SMILES	C1=NC2=C(N1)C(=O)NS(=O)(=O)N2
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem. 2007 Apr 27;282(17):13033-46.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.3143 mL	26.5717 mL	53.1434 mL
	5 mM	1.0629 mL	5.3143 mL	10.6287 mL
	10 mM	0.5314 mL	2.6572 mL	5.3143 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.