ARM1 (4BSA) is a potent inhibitor of aminopeptidases and epoxide hydrolases. The inhibitory activity of ARM1 against aminopeptidase is IC50 7.61 µM, and the inhibitory activity against epoxide hydrolase is IC50 12.4 µM.

Physicochemical Properties

Molecular Formula	C16H14N2S
Molecular Weight	266.360762119293
Exact Mass	266.087
CAS #	68729-05-5
PubChem CID	3768902
Appearance	Off-white to light yellow solid powder
Density	1.2±0.1 g/cm3
Boiling Point	462.7±24.0 °C at 760 mmHg
Flash Point	233.6±22.9 °C
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.660
LogP	4.13
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	19
Complexity	270
Defined Atom Stereocenter Count	0
InChi Key	XYDVHKCVOMGRSY-UHFFFAOYSA-N
InChi Code	InChI=1S/C16H14N2S/c17-16-18-15(11-19-16)14-8-6-13(7-9-14)10-12-4-2-1-3-5-12/h1-9,11H,10H2,(H2,17,18)
Chemical Name	4-(4-benzylphenyl)-1,3-thiazol-2-amine
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Synthesis, docking, cytotoxicity, and LTA4H inhibitory activity of new gingerol derivatives as potential colorectal cancer therapy. Bioorg Med Chem. 2017;25(3):1277-1285.

Solubility Data

Solubility (In Vitro)

DMSO : ~250 mg/mL (~938.58 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.08 mg/mL (7.81 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.7543 mL	18.7716 mL	37.5432 mL
	5 mM	0.7509 mL	3.7543 mL	7.5086 mL
	10 mM	0.3754 mL	1.8772 mL	3.7543 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.