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A2315A is a new antibiotics produced by Actinoplanes philippinensis. Antibiotic A2315A is a new member of the virginiamycin family of antibiotics. Physical and chemical data indicate that it is related to ostreogrycin A.
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Physicochemical Properties
| Molecular Formula |
C26H37N3O7
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| Molecular Weight |
503.58788
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| Exact Mass |
503.263
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| CAS # |
58717-24-1
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| Related CAS # |
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| PubChem CID |
6441077
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| Appearance |
Typically exists as solid at room temperature
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| LogP |
2.126
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| Hydrogen Bond Donor Count |
4
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| Hydrogen Bond Acceptor Count |
8
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
36
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| Complexity |
855
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| Defined Atom Stereocenter Count |
5
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| SMILES |
OC1CC(O)CC2=NC(=CO2)C(=O)NC(C)C(=O)OC(C(C)C)C(C)C=CC(=O)NCC=CC(C)=C1 |c:35,t:26,32|
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| InChi Key |
SAQNYTQFLPVTNJ-PPIFFTIDSA-N
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| InChi Code |
InChI=1S/C26H37N3O7/c1-15(2)24-17(4)8-9-22(32)27-10-6-7-16(3)11-19(30)12-20(31)13-23-29-21(14-35-23)25(33)28-18(5)26(34)36-24/h6-9,11,14-15,17-20,24,30-31H,10,12-13H2,1-5H3,(H,27,32)(H,28,33)/b7-6+,9-8+,16-11+/t17-,18-,19-,20-,24-/m1/s1
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| Chemical Name |
(4R,7R,8R,9E,14E,16E,18S,20R)-18,20-dihydroxy-4,8,16-trimethyl-7-propan-2-yl-6,23-dioxa-3,12,25-triazabicyclo[20.2.1]pentacosa-1(24),9,14,16,22(25)-pentaene-2,5,11-trione
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| Synonyms |
| Madumycin II; A2315A; A 2315A; A-2315A |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder-20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Biological Activity
| ln Vitro |
In vitro activity:
Kinase Assay:
Cell Assay: |
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| ln Vivo |
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| Animal Protocol |
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| References |
J Antibiot (Tokyo).1977 Mar;30(3):197-201.
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| Additional Infomation |
Madumicin II has been reported in Actinoplanes and Actinoplanes philippinensis with data available.
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Solubility Data
| Solubility (In Vitro) |
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| Solubility (In Vivo) |
(Please use freshly prepared in vivo formulations for optimal results.)
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| Preparing Stock Solutions |
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1 mg |
5 mg |
10 mg |
| 1 mM |
1.9857 mL |
9.9287 mL |
19.8574 mL |
| 5 mM |
0.3971 mL |
1.9857 mL |
3.9715 mL |
| 10 mM |
0.1986 mL |
0.9929 mL |
1.9857 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles. |
