8-Chloroquinazolin-4-ol (Compd 18) is an inhibitor of PARP-1 enzyme with IC50 value of 5.65 μM.

Physicochemical Properties

Molecular Formula	C8H5CLN2O
Molecular Weight	180.59
CAS #	101494-95-5
Appearance	Solid powder
SMILES	ClC1=C2N=CNC(=O)C2=CC=C1
Synonyms	8-Chloro-4-quinazolinone
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors. Eur J Med Chem. 2012 Apr:50:264-73.

Solubility Data

Solubility (In Vitro)

DMSO : ~5 mg/mL (~27.69 mM; with ultrasonication (<60°C))

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 0.5 mg/mL (2.77 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.5374 mL	27.6870 mL	55.3741 mL
	5 mM	1.1075 mL	5.5374 mL	11.0748 mL
	10 mM	0.5537 mL	2.7687 mL	5.5374 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.