7-Methylcoumarin is a coumarin with strong hepatoprotective activity and potent antioxidant effect.

Physicochemical Properties

Molecular Formula	C10H8O2
Molecular Weight	160.1693
Exact Mass	160.052
CAS #	2445-83-2
PubChem CID	17131
Appearance	White to off-white solid powder
Density	1.2±0.1 g/cm3
Boiling Point	313.1±0.0 °C at 760 mmHg
Melting Point	128-130 °C(lit.)
Flash Point	125.9±19.5 °C
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.583
LogP	1.85
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	12
Complexity	220
Defined Atom Stereocenter Count	0
InChi Key	DLHXRDUXNVEIEY-UHFFFAOYSA-N
InChi Code	InChI=1S/C10H8O2/c1-7-2-3-8-4-5-10(11)12-9(8)6-7/h2-6H,1H3
Chemical Name	7-methylchromen-2-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Ameliorative effects of 7-methylcoumarin and 7-methoxycoumarin against CCl4-induced hepatotoxicity in rats. Drug Chem Toxicol. 2013 Jan;36(1):42-7.
Additional Infomation	7-Methylcoumarin is a member of coumarins.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~624.34 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (15.61 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.61 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.2434 mL	31.2168 mL	62.4337 mL
	5 mM	1.2487 mL	6.2434 mL	12.4867 mL
	10 mM	0.6243 mL	3.1217 mL	6.2434 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.