7-Methoxy-4-methyl-coumarin-8-ol (compound 31) is a compound extracted from lime (Citrus aurantium).

Physicochemical Properties

Molecular Formula	C11H10O4
Molecular Weight	206.1947
Exact Mass	206.057
CAS #	22084-94-2
PubChem CID	596086
Appearance	White to off-white solid powder
Density	1.3±0.1 g/cm3
Boiling Point	383.2±42.0 °C at 760 mmHg
Flash Point	154.4±21.4 °C
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.588
LogP	1.61
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	15
Complexity	297
Defined Atom Stereocenter Count	0
InChi Key	HHSJFOILNWMNFO-UHFFFAOYSA-N
InChi Code	InChI=1S/C11H10O4/c1-6-5-9(12)15-11-7(6)3-4-8(14-2)10(11)13/h3-5,13H,1-2H3
Chemical Name	8-hydroxy-7-methoxy-4-methylchromen-2-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Phenolics in Citrus aurantium fruit identified by UHPLC-MS/MS and their bioactivities.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~484.99 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (12.12 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.8499 mL	24.2495 mL	48.4990 mL
	5 mM	0.9700 mL	4.8499 mL	9.6998 mL
	10 mM	0.4850 mL	2.4249 mL	4.8499 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.