5-AIQ hydrochloride is a water-soluble PARP-1 inhibitor. 5-AIQ hydrochloride is an important functional group in many drugs. 5-AIQ hydrochloride reduces tissue damage associated with liver ischemia-reperfusion and can be used to study conditions related to liver ischemia-reperfusion.

Physicochemical Properties

Molecular Formula	C9H9CLN2O
Molecular Weight	196.63
CAS #	93117-07-8
SMILES	C1=CC2=C(N=CC=C2C(=C1)N)O.Cl
Synonyms	5-Aminoisoquinolin-1-one hydrochloride
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Vinod KR, Chandra S, Sharma SK. Evaluation of 5-aminoisoquinoline (5-AIQ), a novel PARP-1 inhibitor for genotoxicity potential in vitro and in vivo. Toxicol Mech Methods. 2010 Feb;20(2):90-5. [2]. The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat. Med Sci Monit. 2002 Nov;8(11):BR444-53.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	5.0857 mL	25.4285 mL	50.8569 mL
	5 mM	1.0171 mL	5.0857 mL	10.1714 mL
	10 mM	0.5086 mL	2.5428 mL	5.0857 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.