3-Amino-2-piperidinone is a delta-lactam and a metabolite from all living organisms. As a delta-lactam, it is 2-piperidone substituted at position 3 by an amino group.

Physicochemical Properties

Molecular Formula	C₅H₁₀N₂O
Molecular Weight	114.15
Exact Mass	114.079
CAS #	1892-22-4
PubChem CID	5200225
Appearance	Yellow to brown solid powder
Density	1.1±0.1 g/cm3
Boiling Point	307.5±35.0 °C at 760 mmHg
Flash Point	139.8±25.9 °C
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.477
LogP	-2.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	8
Complexity	103
Defined Atom Stereocenter Count	0
InChi Key	YCCMTCQQDULIFE-UHFFFAOYSA-N
InChi Code	InChI=1S/C5H10N2O/c6-4-2-1-3-7-5(4)8/h4H,1-3,6H2,(H,7,8)
Chemical Name	3-aminopiperidin-2-one
Synonyms	3Amino2piperidinone 3 Amino 2 piperidinone
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage.(2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Additional Infomation

3-aminopiperidine-2-one is a delta-lactam that is 2-piperidone substituted at position 3 by an amino group. It has a role as a human metabolite. It is a member of piperidones, a primary amino compound and a delta-lactam. 3-Amino-2-piperidone is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). 3-Aminopiperidin-2-one has been reported in Ascochyta medicaginicola, Arabidopsis thaliana, and Vitis vinifera with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~50 mg/mL (~438.02 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (21.90 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (21.90 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	8.7604 mL	43.8020 mL	87.6040 mL
	5 mM	1.7521 mL	8.7604 mL	17.5208 mL
	10 mM	0.8760 mL	4.3802 mL	8.7604 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.