2-Bromo-6-nitrophenol can be converted to N-acetyl-2-bromo-6-aminophenol by 2-bromo-6-aminophenol.

Physicochemical Properties

Molecular Formula	C6H4BRNO3
Molecular Weight	218.01
Exact Mass	216.937
CAS #	13073-25-1
PubChem CID	13545453
Appearance	Light brown to yellow solid powder
Density	1.9±0.1 g/cm3
Boiling Point	227.2±20.0 °C at 760 mmHg
Melting Point	66-70 °C(lit.)
Flash Point	91.2±21.8 °C
Vapour Pressure	0.1±0.5 mmHg at 25°C
Index of Refraction	1.652
LogP	2.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	0
Heavy Atom Count	11
Complexity	158
Defined Atom Stereocenter Count	0
SMILES	C1=C([N+]([O-])=O)C(=C(Br)C=C1)O
InChi Key	VEJSIOPQKQXJAT-UHFFFAOYSA-N
InChi Code	InChI=1S/C6H4BrNO3/c7-4-2-1-3-5(6(4)9)8(10)11/h1-3,9H
Chemical Name	2-bromo-6-nitrophenol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. D B Harper, et al. Studies on plant growth-regulating substances. 31. The metabolism of certain 2,6-disubstituted phenols within plant tissues. Ann Appl Biol. 1971 Apr;67(3):395-408.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (458.69 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (11.47 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.47 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.5869 mL	22.9347 mL	45.8695 mL
	5 mM	0.9174 mL	4.5869 mL	9.1739 mL
	10 mM	0.4587 mL	2.2935 mL	4.5869 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.