1-Aminocyclobutanecarboxylic acid is a partial NMDA receptor agonist (activator) acting on the NR1 glycine site.

Physicochemical Properties

Molecular Formula	C5H9NO2
Molecular Weight	115.13
Exact Mass	115.063
CAS #	22264-50-2
PubChem CID	89643
Appearance	Off-white to gray solid powder
Density	1.3±0.1 g/cm3
Boiling Point	241.1±23.0 °C at 760 mmHg
Melting Point	261ºC (dec.)
Flash Point	99.6±22.6 °C
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.540
LogP	-0.62
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Heavy Atom Count	8
Complexity	118
Defined Atom Stereocenter Count	0
InChi Key	FVTVMQPGKVHSEY-UHFFFAOYSA-N
InChi Code	InChI=1S/C5H9NO2/c6-5(4(7)8)2-1-3-5/h1-3,6H2,(H,7,8)
Chemical Name	1-aminocyclobutane-1-carboxylic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron. 2005 Jul 7;47(1):71-84.
Additional Infomation	1-AMINOCYCLOBUTANE CARBOXYLIC ACID is a L-alpha-amino acid.

Solubility Data

Solubility (In Vitro)	H2O: 27.78 mg/mL (241.29 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 33.33 mg/mL (289.50 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	8.6858 mL	43.4292 mL	86.8583 mL
	5 mM	1.7372 mL	8.6858 mL	17.3717 mL
	10 mM	0.8686 mL	4.3429 mL	8.6858 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.