(R)-Preclamol is a dopamine (DA) agonist/activator with autoreceptor and postsynaptic receptor stimulating properties. (R)-Preclamol inhibits locomotor activity in mice and rats at low doses.

Physicochemical Properties

Molecular Formula	C14H21NO
Molecular Weight	219.32
Exact Mass	219.162
CAS #	85976-54-1
Related CAS #	Preclamol hydrochloride;88768-67-6;(R)-Preclamol hydrochloride;89874-80-6
PubChem CID	202478
Appearance	Typically exists as solid at room temperature
LogP	2.919
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Heavy Atom Count	16
Complexity	207
Defined Atom Stereocenter Count	1
SMILES	C(N1CCC[C@H](C2C=CC=C(O)C=2)C1)CC
InChi Key	HTSNFXAICLXZMA-ZDUSSCGKSA-N
InChi Code	InChI=1S/C14H21NO/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3/t13-/m0/s1
Chemical Name	3-[(3R)-1-propylpiperidin-3-yl]phenol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	dopamine[1]
References	[1]. Hjorth S, et al. Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP. [2]. Arnt J, et al. Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers. Psychopharmacology (Berl). 1983;81(3):199-207.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (455.95 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (11.40 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.40 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.5595 mL	22.7977 mL	45.5955 mL
	5 mM	0.9119 mL	4.5595 mL	9.1191 mL
	10 mM	0.4560 mL	2.2798 mL	4.5595 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.