| Description | YM 16638 is an orally active leukotriene (LT) antagonist with triglyceride-lowering and peroxisome-increasing effects that can be used to study antigen-induced early and late airway responses in allergic sheep. |
| Synonyms | YM 638, YM-16638, YM16638 |
| molecular weight | 442.57 |
| Molecular formula | C18H22N2O5S3 |
| CAS | 104073-72-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Goto S,et al. Species specificity in the blood cholesterol-lowering effect of YM-16638. Br J Pharmacol. 1996 May;118(1):174-8. 2. Goto S, et al. Effect of the hypocholesterolemic agent YM-16638 on cholesterol biosynthesis activity and apolipoprotein B secretion in HepG2 and monkey liver. Jpn J Pharmacol. 1999 Jan;79(1):75-82. 3. Tomioka K, et al. The effect of an orally active leukotriene (LT) antagonist YM-16638 on antigen-induced early and late airway responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids. 1989 Apr;36(1):43-7. 4. Miyata K, et al. Gastric mucosal protection by YM638, a novel leukotriene D4 receptor antagonist, in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):165-75. |