| Description | YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM. |
| In vitro | YKL 06-062（0.0004-16 μM；3小时）以剂量依赖的方式提高MITF mRNA表达。[1] |
| Target activity | SIK3:2.86 nM, SIK1:2.12 nM, SIK2:1.40 nM |
| molecular weight | 525.69 |
| Molecular formula | C31H39N7O |
| CAS | 2172617-16-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: ＜1 mg/mL (insoluble or slightly soluble), Sonication is recommended. |
| References | 1. Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017;19(11):2177-2184. |