| Description | yGsy2p-IN-1 is a potent yeast glycogen synthase 2 (yGsy2p) and human glycogen synthase 1 (hGYS1) inhibitor. yGsy2p-IN-H23 a pyrazole inhibitor,and is used for glycogen storage diseases (GSDs) |
| Target activity | GYS1 (human):2.75 µM (IC50), GYS1 (WT, human):1.31 µM (Ki) |
| molecular weight | 352.26 |
| Molecular formula | C16H11F3N2O4 |
| CAS | 2415003-97-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 62.5 mg/mL (177.43 mM), Sonication is recommended. |
| References | 1. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551. |