| Description | WWL229 is a selective inhibitor of Ces3 . WWL229 acts by inhibiting recombinant Ces3 but not Ces1f, ABHD6 or other tested serine hydrolases, and recapitulating the effects of WWL113 in adipocytes. |
| molecular weight | 322.36 |
| Molecular formula | C16H22N2O5 |
| CAS | 1338575-28-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 60 mg/mL (186.13 mM) |
| References | 1. Sun K . A Unique Role of Carboxylesterase 3 (Ces3) in β-Adrenergic Signaling Stimulated Thermogenesis. 2019. 2. Inactivation of CES1 Blocks Prostaglandin D2 Glyceryl Ester Catabolism in Monocytes/Macrophages and Enhances Its Anti-inflammatory Effects, Whereas the Pro-inflammatory Effects of Prostaglandin E2 Glyceryl Ester Are Attenuated[J]. ACS Omega, 2020, 5(45):29177-29188. |