| Description | Lofendazam (Bu 1014) is a benzodiazepine derivative that has sedative and anxiolytic effects. |
| Synonyms | Bu 1014 |
| molecular weight | 272.73 |
| Molecular formula | C15H13ClN2O |
| CAS | 29176-29-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (165 mM) |
| References | 1. Tutar Y. Diazepine Derivative Compounds as Heat Shock Protein 90 Inhibitor in Oncology. Drug Des, 2015;4: 127. 2. Malik F, et al. Syntheses and CD studies of optically active substituted 1, 3, 4, 5‐tetrahydro‐2H‐1, 5‐benzodiazepin‐2‐ones. Liebigs Annalen. 1995;1995(10): 1861-1869. 3. Aversa M C, et al. Nuclear magnetic resonance spectra of psychotherapeutic agents. V*—conformational analysis of 1, 3, 4, 5‐tetrahydro‐2H‐1, 5‐benzodiazepin‐2‐ones. Organic Magnetic Resonance. 1981;15(4): 394-398. 4. Husser J, et al. Klinische Prüfung eines neuen Benzodiazepinderivates als Doppelblindstudie mit Hilfe der Wittenborn-Psychiatric-Rating-Scale [Clinical trial of a novel benzodiazepine derivative in a double-blind study using the Wittenborn psychiatric rating scale (author's transl)]. Arzneimittelforschung. 1975;25(10):1650. |