| Description | WJ460 is an effective inhibitor of myoferlin. WJ460 exerts anti-metastatic activity in breast cancer cells. |
| In vitro | WJ460 dose-dependently blocks breast cancer cell invasion through Collagen I(IC50: 43.37 nM in MDA-MB-231 and 36.40 nM in BT549 cells)[1]. |
| In vivo | In a spontaneous metastasis model, WJ460 inhibits angiogenesis, breast tumor growth, and spontaneous metastasis [1]. |
| molecular weight | 460.59 |
| Molecular formula | C27H28N2O3S |
| CAS | 1415251-36-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 200 mg/mL (434.2 mM), Sonication is recommended. |
| References | 1. Zhang T, et al. A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer. Nat Commun. 2018 Sep 13;9(1):3726. |