| Description | GBR 12783 dihydrochloride (GBR12783 2HCl) is a specific, potent and selective dopamine uptake inhibitor. GBR 12783 dihydrochloride inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats. |
| In vivo | GBR 12783（10 mg/kg；腹膜内注射；持续100分钟；雄性Sprague-Dawley大鼠）处理仅在瞬时激活的突触中特异性强化多巴胺传递，提高海马区ACh释放，并在被动回避任务中改善记忆表现[1]。 |
| Synonyms | GBR12783 2HCl |
| molecular weight | 485.49 |
| Molecular formula | C28H34Cl2N2O |
| CAS | 67469-75-4 |
| Storage | |Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (92.69 mM) |
| References | 1. Nail-Boucherie K, et al. The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release. Brain Res Cogn Brain Res. 1998 Oct;7(2):203-5. 2. Bonnet JJ, et al. GBR 12783, a potent and selective inhibitor of dopamine uptake: biochemical studies in vivo and ex vivo. Eur J Pharmacol. 1986 Feb 18;121(2):199-209. |