| Description | Compounds 35 are superior inhibitors of Ebola (Mayinga) and Marburg (Angola) infectious viruses. |
| In vitro | 化合物35是出色的埃博拉病毒（Mayinga）和马尔堡病毒（Angola）的抑制剂。在血浆和肝微粒体（大鼠和人类）中，化合物35展示了良好的代谢稳定性，而且32并未抑制CYP3A4或CYP2C9。这些4-(氨甲基)Benzamide具有作为非洲热病毒进入抑制剂进一步优化的潜力，有望作为治疗和控制埃博拉病毒感染的治疗剂发展。 |
| molecular weight | 461.52 |
| Molecular formula | C25H30F3N3O2 |
| CAS | 2479465-67-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 6.00 mg/mL |
| References | 1. Gaisina I N , Peet N P , Wong L , et al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections[J]. Journal of Medicinal Chemistry, 2020, XXXX(XXX). |