| Description | AS2717638 is an orally active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist (IC50: 38 nM for hLPA5). It also significantly improves PGF2α-, PGE2-, and AMPA-induced allodynia. |
| Target activity | LPA5 (human):38 nM |
| molecular weight | 447.48 |
| Molecular formula | C25H25N3O5 |
| CAS | 2148339-28-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 54 mg/mL (120.7 mM), Sonication is recommended. |
| References | 1. Murai N, et al. Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents. Neuropharmacology. 2017 Nov;126:97-107. |