| Description | VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively). |
| In vitro | VU6005649是能穿透中枢神经系统的mGlu7/8受体激动剂，对mGlu7受体和mGlu8受体的EC50分别为0.65 μM和2.6 μM。VU6005649是 mGlu7正向异构调节剂。 |
| In vivo | 在野生型小鼠中，VU6005649 促进认知效果，影响了关联学习。 |
| Target activity | mGlu8 receptor: 2.6 μM , mGlu7 receptor:(EC50)0.65 μM |
| molecular weight | 357.28 |
| Molecular formula | C16H12F5N3O |
| CAS | 2137047-43-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/ml (167.94 mM), Sonication is recommended. |
| References | 1. Abe M, et al. Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines. ACS Med Chem Lett. 2017 Sep 1;8(10):1110-1115. |