| Description | VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents. |
| Target activity | mGluR3:392 nM |
| molecular weight | 387.8 |
| Molecular formula | C18H15ClFN5O2 |
| CAS | 1809085-30-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: insoluble DMSO: 240 mg/mL (618.88 mM), Sonication is recommended. |
| References | 1. Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500. |