| Description | NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2), which reduces glur6 receptor-mediated currents, and inhibits specific binding to the glur6 receptor. |
| In vitro | NS-102 作为 AMPA receptor 拮抗剂 在 10 μM浓度下和 GYKI 52466 (30 μM) 的联合使用可在氧气和葡萄糖剥夺 (OGD) 期间防止复合动作电位 (CAP) 的完全丧失，并增加 CAP 面积恢复[1]。 |
| In vivo | NS-102 (20-80 μM）在海马 CA3 区能够显著降低七氟醚诱导的多动症[1]。 |
| Synonyms | NS 102, NS102 |
| molecular weight | 261.23 |
| Molecular formula | C12H11N3O4 |
| CAS | 136623-01-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2 mg/mL (7.6 mM), Sonication is recommended. |
| References | 1. Selva Baltan Tekkök, et al. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J Cereb Blood Flow Metab. 2007 Sep;27(9):1540-52. 2. P Liang, et al. Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model. Br J Anaesth. 2017 Nov 1;119(5):1047-1054. 3. Barbara Gisabella, et al. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012;7(3):e32483. 4. erdoorn TA, Johansen TH, Drejer J, Nielsen EO. Selective block of recombinant glur6 receptors by NS-102, a novel non-NMDA receptor antagonist. Eur J Pharmacol. 1994 Sep 15;269(1):43-9. |