| Description | VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively. |
| In vitro | VU0483605 shows excellent mGlu1 PAM activity at both human and rat (pEC50 = 6.45 ± 0.11, 113 ± 5% Glu Max) and no activity as an mGlu4 PAM (EC50 >10 μM)[1]. |
| molecular weight | 446.67 |
| Molecular formula | C20H10Cl3N3O3 |
| CAS | 1623101-11-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 95 mg/mL (212.68 mM), Sonication is recommended. |
| References | 1. Cho HP, Garcia-Barrantes PM, Brogan JT, et al. Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. ACS Chem Biol. 2014;9(10):2334-2346. |