| Description | VU-1545 is mGlu5 positive allosteric modulator. |
| Target activity | mGluR5:156 nM (Ki), mGluR5:9.6 nM (EC50) |
| Synonyms | VU 1545 |
| molecular weight | 402.38 |
| Molecular formula | C22H15FN4O3 |
| CAS | 890764-63-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (124.26 mM) |
| References | 1. Paulis T D , Hemstapat K , Chen Y , et al. Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes.[J]. Journal of Medicinal Chemistry, 2006, 49(11):3332-44. |