| Description | JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection. |
| In vivo | JNJ-46778212 在大鼠中具有抗精神病样活性可剂量依赖性（3-56.6 mg/kg，po）逆转 AHL[1]。 |
| Target activity | mGlu5:260 nM (EC50) |
| Synonyms | VU 0409551 |
| molecular weight | 352.36 |
| Molecular formula | C20H17FN2O3 |
| CAS | 1363281-27-9 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 80 mg/mL (227.04 mM), Sonication is recommended. |
| References | 1. Conde-Ceide S,et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia. ACS Med Chem Lett. 2015 May 20;6(6):716-20. |