| Description | VP-4604 is a potent anti-methicillin-resistant Staphylococcus aureus (MRSA) compound. VP-4604 exhibited significant microbial growth inhibition against S. aureus with an MIC of 4-8 μg/mL. VP-4604 inhibited the growth of methicillin-resistant S. aureus with a growth inhibition rate of over 95%. |
| In vitro | VP-4604（2.5 mM）对哺乳动物细胞显示出低毒性，并被哺乳动物细胞（HaCaT，淋巴细胞）所耐受，抑制生长率（%）分别为44.1%和>50%。[1] 在18小时的处理下，VP-4604（2.5 mM）能够抑制耐药性的S. aureus和P. aeruginosa，生长抑制率（GI）>95%。[1] 对于HEK-293（人类胚胎肾细胞）ATCC CRL‐1573和RBC（人类红细胞），VP-4604表现出低细胞毒性，其CC 50值>118.4 mM以及HC 10值>118.4 μM。[1] |
| Target activity | S. aureus:4-8 µg/mL(MIC) |
| Synonyms | 1-((4-Nitrophenyl)sulfonyl)piperidine |
| molecular weight | 270.3 |
| Molecular formula | C11H14N2O4S |
| CAS | 64268-93-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 6 mg/mL (22.2 mM), Sonication is recommended. |
| References | 1. Palchykov V, et al. Antimicrobial action of arylsulfonamides bearing (aza) norbornane and related motifs: evaluation of new promising anti-MRSA agents. Medicinal Chemistry Research, 2022: 1-9. |