| Description | Lappaconitine hydrobromide (Allapinine) is a kind of alkaloid extracted from Aconitum sinomontanum Nakai. It has anti-inflammatory effects. |
| In vitro | Lappaconite Hydrobromide是从Aconitum sinomontanum Nakai中提取的一种生物碱，具有抗炎作用。在大鼠胃部给药后，其吸收百分比为9.67%。十二指肠、空肠、回肠和结肠的吸收百分比分别为19.61%、11.83%、12.95%和9.51%。当浓度从10 mg/L提高到40 mg/L时，Lappaconite Hydrobromide的吸收量线性增加，但吸收速率常数保持不变。[1] |
| In vivo | LD50：在小鼠中为10.5 mg/kg（i.p.）；在大鼠中为9.9 mg/kg（i.p.）[2]。 |
| Synonyms | 氢溴酸高乌甲素, Lappaconite HBr, Allapinine |
| molecular weight | 665.61 |
| Molecular formula | C32H44N2O8·HBr |
| CAS | 97792-45-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 28 mg/mL (42.06 mM) Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Vakhitova IuV, et al. To the mechanisms of antiarrhythmic action of Allapinine. Bioorg Khim, 2013, 39 (1):105-16 2. Abdalla A., et al. Allapinine pharmacodynamics and potential adverse effects. Kardiologiya. 29(7): 29-32 |