| Description | Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.Vofopitant dihydrochloride is a potential compound for the treatment of pathological vomiting. Vofopitant dihydrochloride is a potential compound for the treatment of pathological vomiting. |
| Target activity | NK1 (human):10.6 (pKi), NK1 (rat):9.5 (pKi) |
| Synonyms | GR 205171A, Vofopitant 2HCl |
| molecular weight | 505.36 |
| Molecular formula | C21H25Cl2F3N6O |
| CAS | 168266-51-1 |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 20 mg/mL (39.58 mM), Sonication is recommended. DMSO: 20 mg/mL (39.58 mM), Sonication is recommended. |
| References | 1. Gardner CJ, et al. GR205171: a novel antagonist with high affinity for the tachykinin NK1 receptor, and potent broad-spectrum anti-emetic activity. Regul Pept. 1996 Aug 27;65(1):45-53. |