| Description | Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against δPI3 kinase is at least 20 times lower than that of the inhibitors against other PI3K isoforms (A, β, and γ). |
| Synonyms | TGR-1202 R-enantiomer, RP5264 R-enantiomer |
| molecular weight | 571.55 |
| Molecular formula | C31H24F3N5O3 |
| CAS | 1532533-69-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 9 mg/mL (15.75 mM) |
| References | 1. Michael Weiss, et al. Combination of anti-cd20 antibody and pi3 kinase selective inhibitor. WO2014071125A1. |