| Description | I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells. |
| In vitro | I-OMe Tyrhost AG 538 (0-3 µM; 1 hour) can prevent the phosphorylation of Akt, IGF-1R, and Erk.[1]I-OMe Tyrphostin AG 538 (0.1-1000 µM; 24 hours) has cytotoxicity on PANC-1 cells in nutrient deficient culture medium.[1] |
| Target activity | PI5P4Kα:1 µM |
| Synonyms | I-OMe-AG 538 |
| molecular weight | 437.19 |
| Molecular formula | C17H12INO5 |
| CAS | 1094048-77-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (114.37 mM), Sonication is recommended. |
| References | 1. Davis MI, et al. A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. PLoS One. 2013;8(1):e54127. 2. Momose I, et al. Inhibitors of insulin-like growth factor-1 receptor tyrosine kinase are preferentially cytotoxic to nutrient-deprived pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Feb 27;380(1):171-6. |