| Description | U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM). |
| In vitro | 在转移性MDA-MB-231LM2-4Luc +细胞中,U-104（<50 μM）以剂量依赖性方式显着降低细胞迁移。 |
| In vivo | 在4T1实验用转移小鼠模型中,U-104（19 mg/kg）可抑制转移形成.植入MDA-MB-231 LM2-4Luc+细胞的小鼠中, U-104（38 mg/kg）抑制原代肿瘤的生长并减少癌症干细胞数量.植入4T1细胞的Balb/c小鼠中,口服给药U-104（5 mg/mL）减缓了肿瘤生长速度. |
| Target activity | CA XII:4.5 nM(Ki), CA IX:45.1 nM(Ki) |
| Synonyms | NSC-213841, MST-104 |
| molecular weight | 309.32 |
| Molecular formula | C13H12FN3O3S |
| CAS | 178606-66-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 40 mg/mL (129.32 mM), Sonication is recommended. |
| References | 1. Lou Y, et al. Cancer Res, 2011, 71(9), 3364-3376. 2. Lock FE, et al. Oncogene, 2012, doi: 10.1038, onc.2012. 550. 3. Pacchiano F, et al. J Med Chem, 2011, 54(6), 1896-1902. |