| Description | Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor. |
| In vitro | Tioxolone中,Benzoxathiol衍生物具有抗细菌,抗真菌和抑制细胞生长的作用,已被用于治疗寻常型银屑病和痤疮的局部治疗. |
| In vivo | Tioxolone具有油调节和抗菌功能,所以被添加到如洗发香波和皮肤清洁剂等一些化妆品中。 |
| Target activity | CA I:91 nM(Ki) |
| molecular weight | 168.17 |
| Molecular formula | C7H4O3S |
| CAS | 4991-65-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 32 mg/mL (190.3 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 45 mg/mL (267.59 mM) |
| References | 1. Byres M, et al. Acta Crystallogr C, 2004 , 60(Pt 6), o395-o396. 2. Kim BH, et al. Exp Mol Med, 2011, 43(5), 313-321. |