| Description | TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease. |
| In vitro | TXNIP-IN-1通过阻断高糖（HG诱导）的TXNIP-TRX复合物形成，降低单核细胞中由高糖诱导的TNF表达（1.25-5 μM）。在THP1细胞、小鼠RAW巨噬细胞及MIN6细胞中，TXNIP-IN-1（分别在1.25-5 μM、0.3-10 μM和5-20 μM; 72小时）能抑制TXNIP mRNA的表达，但在MIN6细胞中不影响TNF-alpha mRNA水平。在人源胰腺1.1B4 beta细胞中，TXNIP-IN-1（0.62-5 μM; 72小时）影响TXNIP和TNF-alpha mRNA的表达。此外，TXNIP-IN-1（5 μM; 16-72小时）能在25mM葡萄糖培养的THP1细胞中抑制c-TRX互作。TXNIP-IN-1还针对人类胰岛的TXNIP mRNA。 |
| molecular weight | 248.23 |
| Molecular formula | C12H12N2O4 |
| CAS | 1268955-50-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 40 mg/mL (161.14 mM), Sonication is recommended. |
| References | 1. Rama Natarajan, et al. Txnip-trx complex inhibitors and methods of using the same. US20200085800A1. |