| Description | Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis. |
| Synonyms | Corr 4a, Corrector C-4, Corr4a, Corrector C 4, Corr-4a |
| molecular weight | 456.97 |
| Molecular formula | C21H17ClN4O2S2 |
| CAS | 421580-53-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (131.3 mM) |
| References | 1. Laselva O,et al. Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains. Mol Pharmacol. 2018 Jun;93(6):612-618. 2. van der Woerd WL, et al. Rescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis. J Hepatol. 2016 Jun;64(6):1339-47. 3. Bali V, et al. A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator. FASEB J. 2016 Jan;30(1):201-13. 4. Dekkers JF,et al. Optimal correction of distinct CFTR folding mutants in rectal cystic fibrosis organoids. Eur Respir J. 2016 Aug;48(2):451-8. |