| Description | Tubulin polymerization-IN-45, a tubulin-targeting agent, acts as a tubulin polymerization inhibitor by binding to the tubulin's colchicine site. It induces apoptotic cell death in hepatocellular cancer (HCC) cells [1]. |
| In vitro | Tubulin polymerization-IN-45（化合物 18）对肝细胞癌（HCC）细胞系展现出有效的活性，其IC50值介于0.6-2.9 μM。此外，该化合物对微管蛋白聚合亦有中等程度的抑制作用，IC50值为19 μM。Tubulin polymerization-IN-45能够引起Huh7与Mahlavu细胞系在G2/M期的细胞周期停滞，并诱导HCC细胞走向凋亡[1]。 |
| molecular weight | 362.38 |
| Molecular formula | C20H18N4O3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |