| Description | BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 10.5 nM for equine BChE (eqBChE) and 32.5 nM for human BChE (hBChE). It exhibits over 1000-fold greater selectivity for BChE compared to acetylcholinesterase (AChE), while also presenting low neurotoxicity and moderate neuroprotective effects [1]. |
| Target activity | AChE:686.4 μM, eqBCHE:10.5 nM, BCHE (human):32.5 nM |
| molecular weight | 535.47 |
| Molecular formula | C23H23BrN2O4S2 |
| CAS | 2425632-57-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |