| Description | Tubulin Inhibitor 33 is a dose-dependent inhibitor of tubulin polymerization, exhibiting an IC50 value of 9.05 μM. This compound demonstrates antitumor activity and induces apoptosis, making it useful for antitumor research [1]. |
| In vitro | 微管蛋白抑制剂33（化合物3a）（0-5 nM；24-48小时）作用于HepG-2肿瘤细胞，有效抑制其增殖、迁移及集落形成，并诱导G2/M期细胞周期阻滞及细胞凋亡[1]。 |
| In vivo | 药物33(化合物3a)以每日腹腔注射5 mg/kg的剂量连续作用14天，能显著抑制黑色素瘤肿瘤的生长, 其总生长抑制率(TGI)为62.96% [1]。 |
| molecular weight | 414.46 |
| Molecular formula | C24H22N4O3 |
| CAS | 2944462-67-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |