| Description | S-F24 is a broad-spectrum antifungal agent that demonstrates potent inhibition of CYP3A4, with an IC50 of 0.4 μM. It exhibits a favorable safety profile, characterized by high selectivity, minimal hemolytic effects, and a reduced propensity for resistance development. S-F24 is useful for fungal infection research [1]. |
| In vitro | S-F24在浓度为10-30 μM且作用时间为48小时的情况下，对哺乳动物细胞的毒性显示较弱[1]。在0.002 μg/mL浓度，并经过20代传代后，S-F24能使C. albicans SC5314的最小抑菌浓度（MIC 80）值提高8倍[1]。此外，0.004 μg/mL的S-F24在16小时内能在C. albicans SC5314中抑制麦角甾醇的合成高达92.03％[1]。 |
| In vivo | S-F24（1.5 mg/kg，i.p.，5天，每天一次）在雌性IRC小鼠中被广泛用于处理C. albicans SC5314，A. fumigatus CGMCC3.7795及耐药C. albicans 24D引发的真菌性侵袭性感染[1]。同时，S-F24（0.5，1 mg/kg，i.p.，5天，每天一次）对于雌性IRC小鼠中C. albicans SC5314所致的皮肤感染表现出显著的抑制效果[1]。 |
| molecular weight | 545.42 |
| Molecular formula | C25H27BrF2N6O |
| CAS | 2946669-78-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |