| Description | Transdermal Peptide acetate(888486-23-5 free base) (TD 1 (peptide) acetate) is a 11-amino acid peptide, binds toNa+/K+-ATPase beta-subunit (ATP1B1), and mainly interacts with the C-terminus of ATP1B1. Transdermal Peptide can enhance the transdermal delivery of many macromolecules.Transdermal Peptide TD 1 Amide is novel peptide designed to enhance transdermal drug delivery. |
| In vitro | 在Transdermal Peptide存在下，由于其与ATP1B1的特异性结合，细胞将上调ATP1B1的水平以维持功能和结构；因此，ATP1B1的表达增加。然而，随着时间的推移，一些Transdermal Peptide分子可能通过胞吞作用被运输进入细胞内；结果是，ATP1B1的表达随之减少。Transdermal Peptide与ATP1B1之间的相互作用不仅改变了ATP1B1的表达，还改变了ATP1B1的定位，进而改变了表皮层的结构。这种相互作用可以通过抑制剂或竞争剂减弱，从而导致大分子药物通过皮肤的传递减少[1]。 |
| Synonyms | TD 1 (peptide) acetate, Transdermal Peptide Disulfide Acetate (888486-23-5 free base) |
| molecular weight | 1121.2 |
| Molecular formula | C42H68N14O18S2 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.5 mM |
| References | 1. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67. |