| Description | TP0556351, a potent and selective inhibitor of matrix metalloproteinase-2 (MMP2), exhibits significant efficacy with an IC50 of 0.2 nM and demonstrates the capability to decrease collagen accumulation in a Bleomycin-induced pulmonary fibrosis mouse model. This compound shows promise as a research tool for idiopathic pulmonary fibrosis (IPF) [1]. |
| In vivo | TP0556351（每日0.03、0.1、0.3或1毫克/千克；皮下注射，连续14天）能减少Bleomycin诱导的肺纤维化小鼠模型肺部的胶原蛋白含量[1]。 |
| Target activity | MMP2:0.2 nM |
| molecular weight | 1067.15 |
| Molecular formula | C50H70N10O16 |
| CAS | 2787582-17-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |