| Description | Ro 31-9790 is a synthetic inhibitor of metalloproteinase (MMP). |
| In vitro | L-selectin shedding from mouse and human lymphocytes inhibited by Ro 31-9790, Jurkat T cells, and human monocytes(IC50 of 0.3-0.4 μM on these cell types.) The IC50 values obtained for Ro 31-9790 are 4.82?±?0.75 μM, 1.16?±?0.27 μM, 0.70?±?0.06 μM, 4.47±?1.27 μM and 0.38?±?0.05 μM for mouse lymphocyte L-selectin shedding, Jurkat L-selectin shedding, human lymphocyte L-selectin shedding, human monocyte L-selectin shedding and human monocyte TNF-α shedding. |
| Synonyms | GI4747 |
| molecular weight | 315.41 |
| Molecular formula | C15H29N3O4 |
| CAS | 145337-55-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Borland G, et al. Tissue inhibitor of metalloproteinases-3 inhibits shedding of L-selectin from leukocytes. J Biol Chem. 1999 Jan 29;274(5):2810-5. |