| Description | TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM. |
| Target activity | TLR7/8/9:43 nM |
| Synonyms | TLR7/8/9-IN-1 |
| molecular weight | 435.6 |
| Molecular formula | C27H37N3O2 |
| CAS | 2180127-82-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 6.11 mg/mL (14.03 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Mussari CP, et al. Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). ACS Med Chem Lett. 2020 Jul 29;11(9):1751-1758. |