| Description | SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for research on acting as an immunological adjuv |
| Synonyms | CL-087, SM 360320, CL 087, 1V136, SM-360320, CL087 |
| molecular weight | 315.33 |
| Molecular formula | C15H17N5O3 |
| CAS | 226907-52-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 120 mg/mL (380.55 mM), Sonication is recommended. |
| References | 1. Hayashi T, et al. Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system. PLoS One. 2012;7(9):e45860. 2. Leroy V, et al. Sgp3 and TLR7 stimulation differentially alter the expression profile of modified polytropic retroviruses implicated in murine systemic lupus. J Autoimmun. 2012 Jun;38(4):361-8. 3. Russo C, et al. Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells. Blood. 2011 May 26;117(21):5683-91. 4. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. |